Erythropoietin Accelerates Functional Recovery After Peripheral Nerve Injury
نویسندگان
چکیده
منابع مشابه
Erythropoietin enhanced recovery after peripheral nerve injury
Peripheral nerve injuries are common disorders affecting the US population and represent a great economic and social burden. Acute injuries to peripheral nerves are most often due to an acute trauma or iatrogenic injury, with the resultant neurological deficit dependent on the injury type and severity. Clinical manifestations include a variable degree of motor and/or sensory deficits, with comp...
متن کاملErythropoietin promotes functional recovery and enhances nerve regeneration after peripheral nerve injury in rats.
BACKGROUND AND PURPOSE EPO has been shown to have beneficial effects in a variety of CNS injury models. The purpose of this study was to evaluate the effects of EPO on nerve regeneration and functional recovery in a rat model of peripheral nerve surgery. MATERIALS AND METHODS The sciatic nerve of the rat with a 10-mm defect was bridged with a silicone rubber tube. Forty adult male Sprague-Daw...
متن کاملEdaravone promotes functional recovery after mechanical peripheral nerve injury
Edaravone has been shown to reduce ischemia/reperfusion-induced peripheral nerve injury. However, the therapeutic effect of edaravone on peripheral nerve injury caused by mechanical factors is unknown. In the present study, we established a peripheral nerve injury model by crushing the sciatic nerve using hemostatic forceps, and then administered edaravone 3 mg/kg intraperitoneally. The sciatic...
متن کاملCrocin Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats
Objective(s): Crocin is a constituent of saffron and has many biological functions. The present study aimed to investigate the effects of intraperitoneal (IP) injection of crocin on sciatic nerve regeneration in male Wistar rats. Materials and Methods: Fifty-four rats were divided into 9 groups: groups 1-4 (intact + normal saline and intact + crocin at doses of 5, 20 and 80 mg/kg, respectively)...
متن کاملLocalized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury
Erythropoietin (EPO) has been demonstrated to exert neuroprotective effects on peripheral nerve injury recovery. Though daily intraperitoneal injection of EPO during a long period of time was effective, it was a tedious procedure. In addition, only limited amount of EPO could reach the injury sites by general administration, and free EPO is easily degraded in vivo. In this study, we encapsulate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Bone and Joint Surgery-American Volume
سال: 2008
ISSN: 0021-9355
DOI: 10.2106/jbjs.g.00557